Author: Dr. Rayan Das & Dr. Koomkoom Khawas
Abstract: The present study had evaluated the effects of sub-lethal doses of Cypermethrin on the ovary and uterus of female mice. Adult mice had been divided into four groups: control, low dose (1. 38 mg/kg), medium dose (2. 76 mg/kg), and high dose (5. 52 mg/kg). The pesticide had been administered orally for 21 consecutive days, and reproductive organs had been processed for histological examination using Hematoxylin and Eosin staining. The results had revealed a dosedependent disruption in ovarian and uterine structures. Ovarian sections from treated groups had exhibited progressive follicular atresia, granulosa cell degeneration, and a marked reduction in corpora lutea compared with controls. Uterine tissues had shown thinning of the endometrial lining, glandular atrophy, and epithelial disorganization, particularly in the high dose group. Statistical analysis had confirmed significant (p< 0. 05) differences in follicle counts and endometrial thickness across groups. The study had concluded that Cypermethrin, even at sub-lethal doses, had impaired female reproductive health by inducing severe histological alterations in the ovary and uterus. These findings had emphasized the reproductive toxicity of synthetic pyrethroids and the necessity for cautious pesticide application and safer alternatives.
Keywords: Cypermethrin, Ovary, Uterus, Follicular Atresia, Endometrial Degeneration, Histopathology, Reproductive Toxicity.
Page No: 105-112