Author: Dr. Rayan Das & Dr. Koomkoom Khawas
Abstract: Cypermethrin, a synthetic pyrethroid pesticide, has been widely applied in agriculture and domestic pest control. The present study was conducted to evaluate the dose-dependent effects of Cypermethrin on the estrous cycle of female mice (Musmusculus). Mice were divided into four groups: control, low dose (1.38 mg/kg), medium dose (2.76 mg/kg), and high dose (5.52 mg/kg), and were administered the compound orally for 15 days. Vaginal smears were collected daily to identify estrous cycle stages. Results indicated that control mice exhibited regular cycling, while low-dose mice displayed slight delays in phase transitions. Medium-dose mice showed prolonged diestrus phases and reduced frequency of estrus. High-dose mice presented severe irregularities, with extended diestrus and near absence of estrus. One-way ANOVA followed by post hoc analysis confirmed significant differences between control and treated groups, particularly at medium and high doses. It was concluded that Cypermethrin altered reproductive function in a dose-dependent manner, emphasizing its potential reproductive toxicity
Keywords: Cypermethrin, Estrous Cycle, Dose-Dependent Effect, Female Mice, Reproductive Toxicology.
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